Zomelis D tablet is combination of dapagliflozin and vildagliptin that helps to control blood sugar level. This medication is an oral anti-diabetic agent, prescribed for type 2 diabetes mellitus along with other medications.
Composition :
Dapagliflozin ………..10 mg
Vildagliptin …………100 mg (as sustained release form)
Mechanism of action:
Reversible sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin lowers renal glucose reabsorption, which causes excess glucose to be excreted in the urine and improves glucose management in individuals with type 2 diabetes mellitus.
The kidney is the only organ where SGLT2 is expressed selectively. The main transporter for reabsorbing glucose into the bloodstream from the glomerular filtrate is SGLT2. Because dapagliflozin reduces renal glucose reabsorption, which causes excess glucose to be excreted in the urine, it improves both fasting and postprandial plasma glucose levels.
The GFR and blood glucose level determine how much glucose the kidney removes from the body through this mechanism. When hypoglycemic, dapagliflozin does not interfere with the body’s normal ability to produce glucose. Dapagliflozin functions without regard to insulin activity or secretion.
Weight loss and calorie reduction are linked to dapagliflozin-induced urine glucose excretion, or glucoseuresis. Dapagliflozin is inhibition of sodium and glucose co-transport is also linked to transient natriuresis and mild diuresis.
Vildagliptin layer action causes immediate and total suppression of DPP-4-activity, which raises endogenous levels of the incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulintroic polypeptide) during fasting and after meals.
Side effects of Zomelis d :
- Hypoglycemia (low blood glucose level)
- Dizziness
- Nausea
- Vomitting
- Fatique
- Urinary tract infection
- weight gain
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
How zomelis d work in the body:
Absorption :
Dapagliflozin was rapidly and well absorbed after oral administration and can be administered with or without food. In the fasting condition, maximal dapagliflozin plasma concentrations were often reached two hours after delivery. After a 10 mg dose is administered, dapagliflozin has an absolute oral bio-availability of 78%. In healthy people, diet has a negligible impact on the pharmacokinetics of dapagliflozin.
Vildagliptin is rapidly absorbed with peak plasma concentrations observed at 1.7 hours. food slightly delays the time to peak plasma concentration to 2.5 hours, but does not alter the overall exposure(AUC). Administration of vildagliptin with food resulted in a decrease plasma concentration (19%). Vildagliptin can be given with or without food. The absolute bio-availability is 85%
Distribution :
Dapagliflozin is approximately 91% protein bound.
The plasma protein binding of vildagliptin is low (9.3%) and vildagliptin distributes equally between plasma and red blood cells.
Metabolism :
Dapagliflozin is a C-linked glucoside, meaning the aglycone component is attached to glucose by a carbon-carbon bond. thereby conferring stability against glucosidase enzymes. The mean plasma terminal half-life for dapagliflozin was 12.9 hours following a single oral dose of dapagliflozin 10mg to healthy subjects. Dapagliflozin is extensively metabolized, primarily to accounted for 61% of a 50 mg.
69% of the dose of vildagliptin in people is eliminated by metabolism. main metabolites, which make up 57% of the dosage and are pharmacologically inactive, are the cyano maiety’s hydrolysis product. They are followed in order by the amide and glucuronide hydrolysis products. According to in vitro research using human renal microsomes, the kidney might be a key organ involved in vildagliptin’s hydrolysis into its main inactive metabolite.
Elimination :
Dapagliflozin and related metabolites are primarily eliminated via urinary excretion, of which less than 2% is unchanged dapagliflozin. 96% of the 50 mg dapagliflozin dosage was recovered, with 75% occurring in urine and 21% in feces. 15% of the dosage was eliminated as parent drug in the feces.
Following oral administration of vildagliptin, approximately 85% of the dose was excreted into the urine and 15% of the dose is recovered in the feces.
HOW TO USE ZOMELIS D TABLET :
Use the medicine exactly as directed. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Tablets should be swallowed as whole and not to be chewed or crushed.
What if i missed to take Zomelis d tablet
Take Zomelis-D Tablet SR as soon as possible if you miss a dose. On the other hand, skip the missed dose and resume your regular schedule if your next dose is almost due. Don’t take two doses at once.
FAQ for Zomelis D :
Is Zomelis D Tablet tablet safe to use?
Yes, when used as prescribed by a physician, the Zomelis-D tablet is safe. It might, however, have certain adverse consequences. It should be taken at the same time every day and at the prescribed dosage for the optimum effects.
Can Zomelis D tablet cause dizziness?
Yes, dizziness or vertigo is a possible adverse effect of taking Zomelis D Tablet. If this happens to you, lie down or sit down until the symptoms go away. Always have some fruit juice or sugary snacks on hand in case you become feeling dizzy while travelling.